Solid Dispersion Phd Thesis

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Keywords: Fusion method, hot melt extrusion method, solid dispersion, solvent evaporation method, stability of solid dispersion, supercritical fluid methods How to cite this URL: Vijay J, Sahadevan JT, Gilhotra RM.

A basic insight into the stability and manufacturing aspects of solid dispersions.

Chron Young Sci [serial online] 2012 [cited 2019 Sep 7];-105. 2012/3/2/95/98668One of the most important problems faced by the drug formulators all over the world is the poor solubility of drug candidates.

Most of the work currently going on in the drug formulation technology field is mainly concentrated on increasing the solubility characteristics of the drug synthesized.

Class 3 drugs have permeation as the rate-limiting factor.

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The strategy for this class of drugs depends on the transport mechanism over the permeation membrane.

A pharmaceutical literature survey related to solid dispersions revealed that the dissolution behavior of a number of poorly water-soluble drugs have been altered with the help of solid dispersion techniques.

The oral bioavailability of Class 2 drugs can be increased.

Discussion on stability of solid dispersions The dissolution characteristics and chemical integrity of a solid dispersion must remain unaltered during its shelf life period.

For accomplishing optimum stability in a solid dispersion, the molecular mobility should be as low as possible.


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