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For selected patients with borderline or unresectable disease, neoadjuvant therapy offers the potential for tumor downstaging, increasing the probability of a margin-negative resection and decreasing the occurrence of lymph node metastasis.
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Klinik und Poliklinik für Viszeral-, Thorax- und Gefäßchirurgie, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany Fax: 49 351 449 210 303 Interests: pancreas cancer; apoptosis; microarrays; signal transduction networks; tumor stroma interaction; prostate cancer; biomarker Dear Colleagues, Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies in industrialized countries.
Genetic analyses of patient samples have shown that the vast majority of those cancers display mutations in KRAS and the p16 locus.
Despite these advancements PDAC shows an overall five-year survival rate of only 5%.
Mice were injected with different concentrations of AC by local or systemic administration.
Changes in tumor progression were assessed by tumor size.Cancers like intraductal papillary mucinous neoplasia are of growing concern to the physicians and researchers in the field.This issue will focus on the recent key findings in the field of pancreatic cancer research and therapy.Of all carcinomas, pancreatic cancer has the highest mortality rate, with one- and five-year survival rates [...] Read more. It is the fourth leading cause of cancer-related death in Germany.Of all carcinomas, pancreatic cancer has the highest mortality rate, with one- and five-year survival rates of 25% and less than 5%, respectively, regardless of the stage at diagnosis.Please select whether you prefer to view the MDPI pages with a view tailored for mobile displays or to view the MDPI pages in the normal scrollable desktop version.This selection will be stored into your cookies and used automatically in next visits.In this review, the most common neoadjuvant strategies will be described, compared and discussed. The expression of the tumor-associated antigen MUC-1 and the u PA receptor on three pancreatic cancer cell lines is reported for cell clusters, human mouse xenografts and lymph node metastases, as well as for human pancreatic cancer tissues, using immuno-histochemistry, confocal microscopy and flow cytometry.The targeting vectors C595 and PAI2 were labeled with the alpha emitting radioisotope , the anti-proliferative effect for tumors was tested at two days post-subcutaneous cell inoculation.It is the fourth leading cause of cancer-related death in Germany.The incidence in 2003/2004 was 16 cases per 100.000 inhabitants.