Brain Tumor Research Papers

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Researchers have developed a new model to optimize radiation therapy and significantly increase the number of tumor cells killed during treatment.

The new mathematical model, outlined in a recent study can use information about where the majority of the cells in a tumor are located allowing for radiation treatment to be administered to the densest area.

A new drug, known as IP1867B, could be used for future treatments of brain tumors.

The research team showed that IP1867B worked with existing cancer treatments boosting their effectiveness and, in some cases, restored sensitivity to some treatments.

The Ivy Brain Tumor Center at the Barrow Neurological Institute, has released the results of its recent Phase 0 clinical trial of the breast cancer drug ribociclib (Kisqali®) for the treatment of recurrent glioblastoma.

The agent, recently approved by the FDA for advanced breast cancer, is part of a newly-discovered class of targeted therapy that undermines cancer cell division and could form the backbone of a new drug cocktail for patients with malignant brain tumors like glioblastoma. Jude Children's Research Hospital and Massachusetts General Hospital, alongside others, have revealed the cells of origin for specific subtypes of medulloblastoma, the most common malignant pediatric brain tumor.

A new therapy for treating glioma, an aggressive brain tumor, was shown to be safe in patients and cleared other important hurdles, according to a phase 1 trial recently published in Science Translational Medicine.

The therapy induces production of a cancer-fighting cytokine in the brain, which could be less toxic and more effective than delivering the cytokine itself intravenously, In their initial report, the researchers focused on diffuse intrinsic pontine gliomas, or DIPG, an inoperable brainstem tumor found in children.

The team concluded that a specific class of drugs have the potential to kill mutant tumor cells.

For the first time, scientists have shown that a new type of immunotherapy can reach and treat brain cancer from the bloodstream in mice.


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